Cow's Milk Intolerance - Medline Abstracts (downloaded 20-May-95) TI- Quantitative estimation of cellular infiltration of the small intestinal mucosa in children with cow's milk and gluten intolerance. AU- Kaczmarski M; Lisiecka M; Kurpatkowska B; Jastrzebska J JN- Acta Med Pol; 30 (3-4) p129-39 PY- 1989 AB- Quantitative estimation of the infiltration by intraepithelial lymphocytes and eosinophils of the mucosa was carried out in 21 children with cow's milk and 35 children with gluten intolerance. Before dietary treatment, a statistically significant increase in the infiltration by LIE in children with milk intolerance to the mean value of 34.1 cells and in children with gluten intolerance to 39.0 cells was found, what statistically significantly differed from the mean value of LIE for the control group (19.0 cells/100 epithelial cells). The eosinophilic infiltration in this phase of the disease was noted in 38% of children with cow's milk intolerance (16.9 cells/mm2) and in 27% of children with gluten intolerance (28.6 cells/mm2). After 8-24 months of elimination diets--a decrease in the mean value of the LIE infiltration in the mucosa was revealed in both treated groups. TI- The contribution of some constitutional factors to the development of cow's milk and gluten intolerance in children. AU- Kaczmarski M; Kurzatkowska B CS- Department of Children's Infectious Diseases, Medical Academy in BiaLystok, Poland. JN- Rocz Akad Med Bialymst; 33-34 p167-76 PY- 89 1988 AB- The role of some constitutional factors in the development of cow's milk and gluten intolerance among hospitalized children was the subject of analysis made by the authors. The patients were hospitalized at the Clinic of Infectious Diseases of Children during 1973-1982. The age of 45 children varied from 5 months to 5 years (gluten intolerance group) and of 50 children it amounted to from 2 months to 5 years (cow's milk intolerance group). In 34% of the family members of the children with milk intolerance and in 4.4% of the family members of the children with gluten intolerance the symptoms of this trait were found. Coeliac disease was observed in 13.3% of the family members of the gluten intolerance group of children and 10.8% psychic and/or diabetes disease among the members. It has been suggested that above illnesses of the family members occur more frequently compared to control group and this finding can speak for the participation of s constitutional (genetic?) factor in the development of this type of intolerance among the members of the family of affected children. TI- The contribution of some environmental factors to the development of cow's milk and gluten intolerance in children. AU- Kaczmarski M; Kurzatkowska B CS- Department of Children's Infectious Diseases of the Medical Academy in Bialystok, Poland. JN- Rocz Akad Med Bialymst; 33-34 p151-65 PY- 89 1988 AB- The analysis performed by the authors includes correlation between certain environmental factors i.e. the kind of food (natural, mixed, artificial), the role of infection and therapy applied (including antibiotic therapy), living conditions (residence place, the age of parents, number of siblings) and the body birth weight and the established food intolerance in children. The patients were hospitalized at the Clinic of Infectious Diseases of Children during 1978-1982. There were 45 children aged from 5 months to 5 years with gluten intolerance and 50 children aged from 2 months to 5 years with cow's milk intolerance. A close correlation between feeding and the development of food intolerance was stated. There had been found that 92% of children were given mixed cow milk already at the 2nd month of life and 46.6% were fed with this protein between the 2nd to the 3rd month of life. The former had cow milk allergy while the latter gluten intolerance. Due to longlasting diarrhea multiple antibiotic therapy was applied in the total group studied. Stool samples taken from the both groups revealed salmonella in 15.5% to 18.0%. Apart from this type of infection agent chemotherapy due to viral, parasitic and parenteral infections was used, too. The above presented findings confirmed significant role of the factors mentioned in the development and further progress of milk or gluten intolerance in the patients. TI- Associated factors of protracted diarrhea. AU- Khoshoo V; Bhan MK CS- Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi. JN- Indian Pediatr; 27 (6) p559-69 PY- Jun 1990 AB- The associated factors in 80 children (less than 2 yrs) with protracted diarrhea (greater than 21 days duration) and weight loss were: secondary carbohydrate intolerance (36): enteric pathogens (non typhoidal salmonella (11), enteropathogenic E. coli 'EPEC' (6), giardia (4), and shigella (3); cow's milk protein intolerance (3), gluten intolerance (3); miscellaneous (5); and undiagnosed enteropathy (9). Three of the EPEC showed localised pattern of adherence in vitro with HEP-2 cells. Most patients with salmonella and EPEC had severe secretory diarrhea with large fecal sodium losses. All 6 patients who died had secretory diarrhea and very high fecal sodium. All but 4 patients could be effectively managed with a chicken puree-glucose-coconut oil based diet. TI- [The provocation test in children with cow-milk protein and gluten intolerance: evaluation of the clinical response and lesions in the mucous membrane of the small intestine] TI- Proba prowokacyjna u dzieci z nietolerancja biaLek mleka krowiego i glutenu: ocena reakcji klinicznych i zmian w bLonie sluzowej jelita cienkiego. AU- Kaczmarski M CS- Kliniki Chorob Zakaznych Dzieci AM w BiaLymstoku. JN- Pol Tyg Lek; 45 (8-9) p161-5 PY- Feb 19-26 1990 AB- Provocation test (re-introduction of the noxious protein) was carried out in two groups of patients: (a) with intolerance to the cow-milk proteins (41 children) treated with milk-free diet for 6-24 months, and (b) with gluten intolerance (26 children) treated with gluten-free diet for 6-36 months. The following parameters were compared: type and frequency of the clinical symptoms seen in these patients prior to the introduction of allergen-free diet. Moreover, the type of observed morphological changes in the small intestine mucosa following provocation test were analysed in the groups of 7 patients. A two-year elimination of milk from the diet produces milk tolerance in about 61% patients; clinical symptoms in the remaining children are diversified. Re-introduction of gluten with the diet (provocation test) produces recurrence of gluten intolerance in 96% of children treated with gluten-free diet for 2-3 years. Recurrence of the disease was accompanied by the atrophy of the intestinal villi. TI- [Clinical aspects of cow milk protein and gluten intolerance in children] TI- Klinika nietolerancji biaLek mleka krowiego i glutenu u dzieci. AU- Kaczmarski M JN- Pol Tyg Lek; 44 (4) p86-8 PY- Jan 23 1989 AB- In two comparative groups of 50 children with cow milk proteins and 45 children with gluten intolerance retrospective analysis of initial symptoms was carried out. The initial symptoms of intolerance included: vomiting, loss of appetite, recurrent diarrhoea, and weight gain disorders. These symptoms closely correlated with the type of nutrition (mixed, artificial) and the duration of exposition to harmful component of the food. The symptoms appeared within first days after birth with peak intensity in 6-8 weeks of life in the group with cow milk proteins intolerance. The symptoms of intolerance were most frequent in children of group II in 7-12 months of life. To prevent food intolerance in Polish children, it is recommended to feed them naturally as long as possible and to introduce flour and 4 basic grains late (after the 6th months of life). TI- Lymphoblastic stimulation test with food proteins in digestive intolerance to cow's milk and in infant diarrheas. AU- Baudon JJ; Mougenot JF; Didry JR CS- Unite de Gastroenterologie Pediatrique, Hopital Trousseau, Paris, France. JN- J Pediatr Gastroenterol Nutr; 6 (2) p244-51 PY- Mar-Apr 1987 AB- The lymphoblastic stimulation test (LST) with cow's milk proteins was performed in 114 infants. In 42 infants, digestive intolerance to cow's milk proteins (CMI) was suspected; withdrawal-rechallenge test confirmed intolerance in 34, and disproved it in the other eight patients. Of the other patients, 17 had acute gastroenteritis, 11 had postgastroenteritis subacute diarrhea, 12 had gluten intolerance, 14 had intractable diarrhea, and 18 had no digestive disorders. Of the 34 infants with CMI, 27 (79%) had a positive LST to one or more cow's milk proteins. Of the 34 positive LST patients, 12 also had soya intolerance; nine of these 12 infants (75%) had positive LST to soya. Of the eight infants who had a negative cow's milk rechallenge test, five (62%) had a positive LST. In the other groups, results were also positive in 12-27% of those having diarrhea of infectious origin or gluten intolerance, and in none of the infants without digestive disorders. Of the 14 cases of severe intractable diarrhea, 12 (86%) were also LST-positive, but CMI could not be excluded. LST was positive, particularly in diarrheas of neonatal origin. Lymphoblastic stimulation was induced more frequently by casein than by beta lactoglobulin, and least frequently by alpha lactalbumin. In conclusion, LST is frequently positive in CMI, but is not sufficiently specific to be a reliable diagnostic examination. TI- [Disaccharidase activity as a diagnostic criterion for the mucosa of the small intestine] TI- Disaccharidasen-Aktivitaten als Beurteilungskriterium der Dunndarmschleimhaut. AU- Stern M; Plettner C JN- Monatsschr Kinderheilkd; 131 (5) p264-8 PY- May 1983 AB- Activities of lactase, sucrase, and maltase were determined in small intestinal biopsies of 125 children with coeliac disease, cow's milk protein intolerance, transient gluten intolerance, nonspecific enteropathies, and controls. Four cases of primary disaccharidase deficiencies could be identified. In the enteropathies, morphometric data were more closely correlated to the degree of the mucosal lesion (r = -0.92 for crypt depth) than were disaccharidase activities (r = 0.61 for lactase). In a stepwise discriminant analysis of the patient groups, based upon immunological, morphometric, and biochemical variables, lactase activity was a valuable secondary criterion, ranking third among the variables used. TI- Histological studies of small-intestinal biopsies from infants with low rate of weight gain. AU- Fallstrom SP; Kristiansson B; Ryd W JN- Acta Pathol Microbiol Scand [A]; 89 (6) p431-8 PY- Nov 1981 AB- Eighty-one children aged 4-18 months with unsatisfactory weight gain were investigated for organic diseases; the investigation included small-intestinal biopsy. Sixteen had total villous atrophy, in most cases due to gluten intolerance. Transient disease, e.g. cow's milk protein intolerance, was probable in 7 children with subtotal atrophy. In 18 children the only abnormal finding was an increased number of inflammatory cells in the mucosa, a finding which was probably of no clinical significance. Planimetric measurement showed good agreement between the mucosal surface/volume ratio and an ordinary histological grouping of the mucosa. A significant correlation was found between the rate of weight gain during the period preceding investigation and mucosal surface/volume ratio.