Cow's Milk Intolerance - Medline Abstracts (downloaded 20-May-95)


TI- Quantitative estimation of cellular infiltration of the small
    intestinal mucosa in children with cow's milk and gluten intolerance.
AU- Kaczmarski M; Lisiecka M; Kurpatkowska B; Jastrzebska J
JN- Acta Med Pol; 30 (3-4) p129-39
PY- 1989
AB- Quantitative estimation of the infiltration by intraepithelial
    lymphocytes and eosinophils of the mucosa was carried out in 21
    children with cow's milk and 35 children with gluten intolerance.
    Before dietary treatment, a statistically significant increase in the
    infiltration by LIE in children with milk intolerance to the mean value
    of 34.1 cells and in children with gluten intolerance to 39.0 cells was
    found, what statistically significantly differed from the mean value of
    LIE for the control group (19.0 cells/100 epithelial cells). The
    eosinophilic infiltration in this phase of the disease was noted in 38%
    of children with cow's milk intolerance (16.9 cells/mm2) and in 27% of
    children with gluten intolerance (28.6 cells/mm2). After 8-24 months of
    elimination diets--a decrease in the mean value of the LIE infiltration
    in the mucosa was revealed in both treated groups.

TI- The contribution of some constitutional factors to the development of
    cow's milk and gluten intolerance in children.
AU- Kaczmarski M; Kurzatkowska B
CS- Department of Children's Infectious Diseases, Medical Academy in
    BiaLystok, Poland.
JN- Rocz Akad Med Bialymst; 33-34 p167-76
PY- 89 1988
AB- The role of some constitutional factors in the development of cow's
    milk and gluten intolerance among hospitalized children was the subject
    of analysis made by the authors. The patients were hospitalized at the
    Clinic of Infectious Diseases of Children during 1973-1982. The age of
    45 children varied from 5 months to 5 years (gluten intolerance group)
    and of 50 children it amounted to from 2 months to 5 years (cow's milk
    intolerance group). In 34% of the family members of the children with
    milk intolerance and in 4.4% of the family members of the children with
    gluten intolerance the symptoms of this trait were found. Coeliac
    disease was observed in 13.3% of the family members of the gluten
    intolerance group of children and 10.8% psychic and/or diabetes disease
    among the members. It has been suggested that above illnesses of the
    family members occur more frequently compared to control group and this
    finding can speak for the participation of s constitutional (genetic?)
    factor in the development of this type of intolerance among the members
    of the family of affected children.

TI- The contribution of some environmental factors to the development of
    cow's milk and gluten intolerance in children.
AU- Kaczmarski M; Kurzatkowska B
CS- Department of Children's Infectious Diseases of the Medical Academy in
    Bialystok, Poland.
JN- Rocz Akad Med Bialymst; 33-34 p151-65
PY- 89 1988
AB- The analysis performed by the authors includes correlation between
    certain environmental factors i.e. the kind of food (natural, mixed,
    artificial), the role of infection and therapy applied (including
    antibiotic therapy), living conditions (residence place, the age of
    parents, number of siblings) and the body birth weight and the
    established food intolerance in children. The patients were
    hospitalized at the Clinic of Infectious Diseases of Children during
    1978-1982. There were 45 children aged from 5 months to 5 years with
    gluten intolerance and 50 children aged from 2 months to 5 years with
    cow's milk intolerance. A close correlation between feeding and the
    development of food intolerance was stated. There had been found that
    92% of children were given mixed cow milk already at the 2nd month of
    life and 46.6% were fed with this protein between the 2nd to the 3rd
    month of life. The former had cow milk allergy while the latter gluten
    intolerance. Due to longlasting diarrhea multiple antibiotic therapy
    was applied in the total group studied. Stool samples taken from the
    both groups revealed salmonella in 15.5% to 18.0%. Apart from this type
    of infection agent chemotherapy due to viral, parasitic and parenteral
    infections was used, too. The above presented findings confirmed
    significant role of the factors mentioned in the development and
    further progress of milk or gluten intolerance in the patients.

TI- Associated factors of protracted diarrhea.
AU- Khoshoo V; Bhan MK
CS- Department of Pediatrics, All India Institute of Medical Sciences,
    Ansari Nagar, New Delhi.
JN- Indian Pediatr; 27 (6) p559-69
PY- Jun 1990
AB- The associated factors in 80 children (less than 2 yrs) with protracted
    diarrhea (greater than 21 days duration) and weight loss were:
    secondary carbohydrate intolerance (36): enteric pathogens (non
    typhoidal salmonella (11), enteropathogenic E. coli 'EPEC' (6), giardia
    (4), and shigella (3); cow's milk protein intolerance (3), gluten
    intolerance (3); miscellaneous (5); and undiagnosed enteropathy (9).
    Three of the EPEC showed localised pattern of adherence in vitro with
    HEP-2 cells. Most patients with salmonella and EPEC had severe
    secretory diarrhea with large fecal sodium losses. All 6 patients who
    died had secretory diarrhea and very high fecal sodium. All but 4
    patients could be effectively managed with a chicken
    puree-glucose-coconut oil based diet.

TI- [The provocation test in children with cow-milk protein and gluten
    intolerance: evaluation of the clinical response and lesions in the
    mucous membrane of the small intestine]
TI- <Original> Proba prowokacyjna u dzieci z nietolerancja biaLek mleka
    krowiego i glutenu: ocena reakcji klinicznych i zmian w bLonie sluzowej
    jelita cienkiego.
AU- Kaczmarski M
CS- Kliniki Chorob Zakaznych Dzieci AM w BiaLymstoku.
JN- Pol Tyg Lek; 45 (8-9) p161-5
PY- Feb 19-26 1990
AB- Provocation test (re-introduction of the noxious protein) was carried
    out in two groups of patients: (a) with intolerance to the cow-milk
    proteins (41 children) treated with milk-free diet for 6-24 months, and
    (b) with gluten intolerance (26 children) treated with gluten-free diet
    for 6-36 months. The following parameters were compared: type and
    frequency of the clinical symptoms seen in these patients prior to the
    introduction of allergen-free diet. Moreover, the type of observed
    morphological changes in the small intestine mucosa following
    provocation test were analysed in the groups of 7 patients. A two-year
    elimination of milk from the diet produces milk tolerance in about 61%
    patients; clinical symptoms in the remaining children are diversified.
    Re-introduction of gluten with the diet (provocation test) produces
    recurrence of gluten intolerance in 96% of children treated with
    gluten-free diet for 2-3 years. Recurrence of the disease was
    accompanied by the atrophy of the intestinal villi.

TI- [Clinical aspects of cow milk protein and gluten intolerance in
    children]
TI- <Original> Klinika nietolerancji biaLek mleka krowiego i glutenu u
    dzieci.
AU- Kaczmarski M
JN- Pol Tyg Lek; 44 (4) p86-8
PY- Jan 23 1989
AB- In two comparative groups of 50 children with cow milk proteins and 45
    children with gluten intolerance retrospective analysis of initial
    symptoms was carried out. The initial symptoms of intolerance included:
    vomiting, loss of appetite, recurrent diarrhoea, and weight gain
    disorders. These symptoms closely correlated with the type of nutrition
    (mixed, artificial) and the duration of exposition to harmful component
    of the food. The symptoms appeared within first days after birth with
    peak intensity in 6-8 weeks of life in the group with cow milk proteins
    intolerance. The symptoms of intolerance were most frequent in children
    of group II in 7-12 months of life. To prevent food intolerance in
    Polish children, it is recommended to feed them naturally as long as
    possible and to introduce flour and 4 basic grains late (after the 6th
    months of life).

TI- Lymphoblastic stimulation test with food proteins in digestive
    intolerance to cow's milk and in infant diarrheas.
AU- Baudon JJ; Mougenot JF; Didry JR
CS- Unite de Gastroenterologie Pediatrique, Hopital Trousseau, Paris,
    France.
JN- J Pediatr Gastroenterol Nutr; 6 (2) p244-51
PY- Mar-Apr 1987
AB- The lymphoblastic stimulation test (LST) with cow's milk proteins was
    performed in 114 infants. In 42 infants, digestive intolerance to cow's
    milk proteins (CMI) was suspected; withdrawal-rechallenge test
    confirmed intolerance in 34, and disproved it in the other eight
    patients. Of the other patients, 17 had acute gastroenteritis, 11 had
    postgastroenteritis subacute diarrhea, 12 had gluten intolerance, 14
    had intractable diarrhea, and 18 had no digestive disorders. Of the 34
    infants with CMI, 27 (79%) had a positive LST to one or more cow's milk
    proteins. Of the 34 positive LST patients, 12 also had soya
    intolerance; nine of these 12 infants (75%) had positive LST to soya.
    Of the eight infants who had a negative cow's milk rechallenge test,
    five (62%) had a positive LST. In the other groups, results were also
    positive in 12-27% of those having diarrhea of infectious origin or
    gluten intolerance, and in none of the infants without digestive
    disorders. Of the 14 cases of severe intractable diarrhea, 12 (86%)
    were also LST-positive, but CMI could not be excluded. LST was
    positive, particularly in diarrheas of neonatal origin. Lymphoblastic
    stimulation was induced more frequently by casein than by beta
    lactoglobulin, and least frequently by alpha lactalbumin. In
    conclusion, LST is frequently positive in CMI, but is not sufficiently
    specific to be a reliable diagnostic examination.

TI- [Disaccharidase activity as a diagnostic criterion for the mucosa of
    the small intestine]
TI- <Original> Disaccharidasen-Aktivitaten als Beurteilungskriterium der
    Dunndarmschleimhaut.
AU- Stern M; Plettner C
JN- Monatsschr Kinderheilkd; 131 (5) p264-8
PY- May 1983
AB- Activities of lactase, sucrase, and maltase were determined in small
    intestinal biopsies of 125 children with coeliac disease, cow's milk
    protein intolerance, transient gluten intolerance, nonspecific
    enteropathies, and controls. Four cases of primary disaccharidase
    deficiencies could be identified. In the enteropathies, morphometric
    data were more closely correlated to the degree of the mucosal lesion
    (r = -0.92 for crypt depth) than were disaccharidase activities (r =
    0.61 for lactase). In a stepwise discriminant analysis of the patient
    groups, based upon immunological, morphometric, and biochemical
    variables, lactase activity was a valuable secondary criterion, ranking
    third among the variables used.

TI- Histological studies of small-intestinal biopsies from infants with low
    rate of weight gain.
AU- Fallstrom SP; Kristiansson B; Ryd W
JN- Acta Pathol Microbiol Scand [A]; 89 (6) p431-8
PY- Nov 1981
AB- Eighty-one children aged 4-18 months with unsatisfactory weight gain
    were investigated for organic diseases; the investigation included
    small-intestinal biopsy. Sixteen had total villous atrophy, in most
    cases due to gluten intolerance. Transient disease, e.g. cow's milk
    protein intolerance, was probable in 7 children with subtotal atrophy.
    In 18 children the only abnormal finding was an increased number of
    inflammatory cells in the mucosa, a finding which was probably of no
    clinical significance. Planimetric measurement showed good agreement
    between the mucosal surface/volume ratio and an ordinary histological
    grouping of the mucosa. A significant correlation was found between the
    rate of weight gain during the period preceding investigation and
    mucosal surface/volume ratio.

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